I just drove my Audi TT from Charlotte to Memphis via Asheville Wed. If I have time I get off I85 at King's Mountain and take 74 through Lake Lure/Chimney Rock to Asheville, scoot around Asheville on I40 to Clyde, then onto 19 by Lake Junaluska, Maggie Valley, and Cherokee. If I have lots of time and am feeling adventurous I will take 19 past Bryson City to 29, which leads to the Tail of the Dragon. That will take you way out of the way but The Dragon is a famous drive and quite a workout. If I don't want to do The Dragon I will take 441 up through Smoky Mountains National Park and Gatlinburg. You can take 321 back to I40 and down to Asheville. That would be a nice drive and not too out of the way. Take your camera - the trees are turning in the higher altitudes.